Yeshumenesh Zegeye, Bogale Aredo, Seher Yuksel, Dogan Can Kirman, Ashwani Kumar, Bo Chen, Emily Turpin, Sangita Shresta, Yu-Guang He, Laurent Gautron, Miao Tang, Xiaohong, Sophia M DiCesare, John D Hulleman, Chao Xing, Sara Ludwig, Eva Marie Y Moresco, Bruce A Beutler, Rafael L Ufret-Vincenty. E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegenerationSci Rep. 2024 Feb 6;14(1):3010. doi: 10.1038/s41598-024-53731-8. PMID: 38321224
Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce Beutler, Lei Sun. Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3KBTBD2Nat Struct Mol Biol. 2024 Feb; 31(2):336-350. doi: 10.1038/s41594-023-01182-6 Epub 2024 Feb 8. PMID: 38332366
Xue Zhong, James J Moresco, Jolene K Diedrich, Antonio M Pinto, Jeffrey A SoRelle, Jianhui Wang, Katie Keller, Sara Ludwig, Eva Marie Y Moresco, Bruce Beutler, Jin Huk Choi. Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasisProc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2314429120. doi: 10.1073/pnas.2314429120. Epub 2023 Dec 6. PMID: 38055739
Xue Zhong, Nagesh Peddada, Jianhui Wang, James J Moresco, Xiaowei Zhan, John M Shelton, Jeffrey A SoRelle, Katie Keller, Danielle Renee Lazaro, Eva Marie Y Moresco, Jin Huk Choi, Bruce Beutler. OVOL2 sustains postnatal thymic epithelial cell identityNat Commun. 2023 Nov 27; 14(1):7786. doi: 10.1038/s41467-023-43456-z. PMID: 38012144
Zhong X, Moresco JJ, Keller K, Lazaro DR, Ely C, Moresco EMY, Beutler B, Choi JH. Essential requirement for IER3IP1 in B cell developmentProc Natl Acad Sci USA. 2023 Nov 14; 120(46):e2312810121.doi: 10.1073/pnas.2312810120. Epub 2023 Nov 7. PMID: 37934820
Zhao Zhang, Yiao Jiang, Lijing Su, Sara Ludwig, Xuechun Zhang, Miao Tang, Xiaohong Li, Priscilla Anderton, Xiaoming Zhan, Mihwa Choi, Jamie Russell, Chun-Hui Bu, Stephen Lyon, Darui Xu, Sara Hildebrand, Lindsay Scott, Jiexia Quan, Rochelle Simpson, Qihua Sun, Baifang Qin, Tiffany Collie, Meron Tadesse, Eva Marie Y Moresco, Bruce Beutler. Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesisCell Metab. 2022 Oct 6;S1550-4131(22)00408-9. PMID: 36228616
Anne-Perrine Foray, Sophie Candon, Sara Hildebrand, Cindy Marquet, Fabrice Valette, Coralie Pecquet, Sebastien Lemoine, Francina Langa-Vives, Michael Dumas, Peipei Hu, Pere Santamaria, Sylvaine You, Stephen Lyon, Lindsay Scott, Chun Hui Bu, Tao Wang, Darui Xu, Eva Marie Y Moresco, Claudio Scazzocchio, Jean-François Bach, Bruce Beutler, Lucienne Chatenoud. De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetesProc Natl Acad Sci USA. 2021 Nov 23;118(47). PMID: 34782469
Lijing Su, Muhammad Athamna, Ying Wang, Junmei Wang, Marina Freudenberg, Tao Yue, Jianhui Wang, Eva Marie Y Moresco, Haoming He, Tsaffrir Zor, Bruce Beutler. Sulfatides are endogenous ligands for the TLR4-MD-2 complexProc Natl Acad Sci USA. 2021 Jul 27;118(30). PMID: 34290146
Darui Xu, Stephen Lyon, Chun Hui Bu, Sara Hildebrand, Jin Huk Choi, Xue Zhong, Aijie Liu, Emre E Turer, Zhao Zhang, Jamie Russell, Sara Ludwig, Elena Mahrt, Evan Nair-Gill, Hexin Shi, Ying Wang, Duanwu Zhang, Tao Yue, Kuan-Wen Wang, Jeffrey A SoRelle, Lijing Su, Takuma Misawa, William McAlpine, Lei Sun, Jianhui Wang, Xiaoming Zhan, Mihwa Choi, Roxana Farokhnia, Andrew Sakla, Sara Schneider, Hannah Coco, Gabrielle Coolbaugh, Braden Hayse, Sara Mazal, Dawson Medler, Brandon Nguyen, Edward Rodriguez, Andrew Wadley, Miao Tang, Xiaohong Li, Priscilla Anderton, Katie Keller, Amanda Press, Lindsay Scott, Jiexia Quan, Sydney Cooper, Tiffany Collie, Baifang Qin, Jennifer Cardin, Rochelle Simpson, Meron Tadesse, Qihua Sun, Carol A Wise, Jonathan J Rios, Eva Marie Y Moresco, Bruce Beutler. Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning.Proc Natl Acad Sci USA. 2021 Jul 13;118(28). PMID: 34260399
Jonathan J Rios, Kristin Denton, Hao Yu, Kandamurugu Manickam, Shannon Garner, Jamie Russell, Sara Ludwig, Jill A Rosenfeld, Pengfei Liu, Jake Munch, Daniel J Sucato, Bruce Beutler, Carol A Wise. Saturation mutagenesis defines novel mouse models of severe spine deformity.Dis Model Mech. 2021 Jun 3. Online ahead of print. PMID: 34079997
Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q Feng, Qian Xu, Yongbo Lu, Robert E Hammer, Carol A Wise, Bruce Beutler. Germline saturation mutagenesis induces skeletal phenotypes in mice.J Bone Miner Res. 2021 Apr 27. Online ahead of print. PMID: 33905568
Lauretta El Hayek, Islam Oguz Tuncay, Nadine Nijem, Jamie Russell, Sara Ludwig, Kiran Kaur, Xiaohong Li, Priscilla Anderton, Miao Tang, Amanda Gerard, Anja Heinze, Pia Zacher, Hessa S Alsaif, Aboulfazl Rad, Kazem Hassanpour, Mohammad Reza Abbaszadegan, Camerun Washington, Barbara R DuPont, Raymond J Louie, CAUSES Study; Madeline Couse, Maha Faden, R Curtis Rogers, Rami Abou Jamra, Ellen R Elias, Reza Maroofian, Henry Houlden, Anna Lehman, Bruce Beutler, Maria H Chahrour. KDM5A mutations identified in autism spectrum disorder using forward genetics. Elife 2020 Dec 22;9:e56883. PMID: 33350388
Darui Xu, Stephen Lyon, Chun Hui Bu, Sara Hildebrand, Jin Huk Choi, Xue Zhong, Aijie Liu, Emre E. Turer, Zhao Zhang, Evan Nair-Gill, Hexin Shi, Ying Wang, Duanwu Zhang, Tao Yue, Jeff SoRelle, Takuma Misawa, Lei Sun, Jianhui Wang, Roxana Farokhnia, Andrew Sakla, Sara Schneider, Nathan Stewart, Hannah Coco, Gabrielle Coolbaugh, Braden Hayse, Sara Mazal, Dawson Medler, Brandon Nguyen, Edward Rodriguez, Andrew Wadley, Miao Tang, Xiaohong Li, Priscilla Anderton, Katie Keller, Lindsay Scott, Jiexia Quan, Sydney Cooper, Baifang Qin, Jennifer Cardin, Rochelle Simpson, Meron Tadesse, Qihua Sun, John Santoyo, Amy Bronikowski, Alexyss Johnson, Eva Marie Y. Moresco, Bruce Beutler.Candidate Explorer: a tool for discovery, evaluation, and display of mutations causing significant immune phenotypes.bioRxiv 2020 Nov 7.
Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler.Mechanism of negative regulation of NF-κB by N4BP1bioRxiv 2020 Oct 22.
Jeffrey A SoRelle, Zhe Chen, Jianhui Wang, Tao Yue, Jin Huk Choi, Kuan-Wen Wang, Xue Zhong, Sara Hildebrand, Jamie Russell, Lindsay Scott, Darui Xu, Xiaowei Zhan, Chun Hui Bu, Tao Wang, Mihwa Choi, Miao Tang, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Eva Marie Y Moresco, Bruce Beutler.Dominant atopy risk mutations identified by mouse forward genetic analysis Allergy 2020 Aug 18. Onlineaheadof print. PMID: 32810290
Michele Carbone, Sarah T Arron, Bruce Beutler, Angela Bononi, Webster Cavenee, James E Cleaver, Carlo M Croce, Alan D'Andrea, William D Foulkes, Giovanni Gaudino, Joanna L Groden, Elizabeth P Henske, Ian D Hickson, Paul M Hwang, Richard D Kolodner, Tak W Mak, David Malkin, Raymond J Monnat Jr, Flavia Novelli, Harvey I Pass, John H Petrini, Laura S Schmidt, Haining Yang. Tumour Predisposition and Cancer Syndromes as Models to Study Gene-Environment Interactions.Nat Rev Cancer. 2020 May 29. Online ahead of print. PMID: 32472073
Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B. Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation. Sci Immunol. 2020 Jan 24;5(43).PMID: 31980486
Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.Proc Natl Acad USA. 2019 July 23;116(30):15184-15193. PMID: 31289229
Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.Science. 2019 May 10;364(6440). PMID: 31073040
McAlpine W, Wang KW, Choi JH, San Miguel M, McAlpine SG, Russell J, Ludwig S, Li X, Tang M, Zhan X, Choi M, Wang T, Bu CH, Murray AR, Moresco EMY, Turer EE, Beutler B. The class I myosin MYO1D binds to lipid and protects against colitis.Dis Model Mech. 2018 Sep 27; 11(9). PMID: 30279225
Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q. Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.Nat Commun. 2018 May 23;9(1):2041. PMID: 29795268
Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, Choi JH, Dosenovic P, Karlsson MCI, Beutler B, Karlsson Hedestam GB.Altered Marginal Zone B Cell Selection in the Absence of IκBNS. J Immunol. 2018 Jan 15;200(2):775-787. Epub 2017 Dec 8. PMID: 29222168
L. Israel, Y. Wang, K. Bulek, E. Della Mina, Z. Zhang, V. Pedergnana, M. Chrabieh, N.A. Lemmens, V. Sancho-Shimizu, M. Descatoire, T. Lasseau, E. Israelsson, L. Lorenzo, L. Yun, A. Belkadi, A. Moran, L.E. Weisman, F. Vandenesch, F. Batteux, S. Weller, M. Levin, J. Herberg, A. Abhyankar, C. Prando, Y. Itan, W.J. van Wamel, C. Picard, L. Abel, D. Chaussabel, X. Li, B.Beutler, P.D. Arkwright, J.L. Casanova, A. Puel. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.Cell 2017 168(5):789-800. PMID: 28235196.
C. Viant, S. Guia, R.J. Hennessy, J. Rautela, K. Pham, C. Bernat, W. Goh, Y. Jiao, R. Delconte, M. Roger, V. Simon, F. Souza-Fonseca-Guimaraes, S. Grabow, G.T. Belz, B.T. Kile, A. Strasser, D. Gray, P.D. Hodgkin, B.Beutler, E. Vivier, S. Ugolini, N.D. Huntington. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.J Exp Med. 2017 Jan 5. PMID:28057804.
C.J. Groß, R. Mishra, K.S. Schneider, G. Médard, J. Wettmarshausen, D.C. Dittlein, H. Shi, O. Gorka, P.A. Koenig, S. Fromm, G. Magnani, T. Ćiković, L. Hartjes, J. Smollich, A.A. Robertson, M.A. Cooper, M. Schmidt-Supprian, M. Schuster, K. Schroder, P. Broz, C. Traidl-Hoffmann, B. Beutler, B. Kuster, J. Ruland, S. Schneider, F. Perocchi, O. Groß. K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity. 2016 Sep 24. PMID:27692612.
O.M. Siggs, A. Stockenhuber, M. Deobagkar-Lele, K.R. Bull, T.L. Crockford, B.L. Kingston, G. Crawford, C. Anzilotti, V. Steeples, S. Ghaffari, G. Czibik, M. Bellahcene, H. Watkins, H. Ashrafian, B. Davies, A. Woods, D. Carling, A. Yavari, B. Beutler, R.J. Cornall. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.Proc Natl Acad Sci U S A 2016 Jun 14. [Epub ahead of print]. PMID:27303042.
Y. Wang, L. Su, M.D. Morin, B.T. Jones, L.R. Whitby, M.M. Surakattula, H. Huang, H. Shi, J.H. Choi, K.W. Wang, E.M. Moresco, M. Berger, X. Zhan, H. Zhang, D.L. Boger, B.Beutler. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.Proc Natl Acad Sci U S A113(7):E884-93, (2016). PMID:26831104.
L.A. Miosge, M.A. Field, Y. Sontani, V. Cho, S. Johnson, A. Palkova, B. Balakishnan, R. Liang, Y. Zhang, S. Lyon, B. Beutler, B. Whittle, E.M. Bertram, A. Enders, C.C. Goodnow, T.D. Andrews. Comparison of predicted and actual consequences of missense mutations.Proc Natl Acad Sci U S A 112(37):E5189-98, (2015). PMCID: PMC4577149.
L.F. Mager, C. Riether, C.M. Schürch, Y. Banz, M.H. Wasmer, R. Stuber, A.P. Theocharides, X. Li, Y. Xia, H. Saito, S. Nakae, G.M. Baerlocher, M.G. Manz, K.D. McCoy, A.J. Macpherson, A.F. Ochsenbein, B.Beutler, P. Krebs. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.J Clin Invest 125(7):2579-91, (2015). PMCID:PMC4563674.
L. von Hertzen, B. Beutler, J. Bienenstock, M. Blaser, P.D. Cani, J. Eriksson, M. Farkkila, T. Haahtela, I. Hanski, M.C. Jenmalm, J. Kere, M. Knip, K. Kontula, M. Koskenvuo, C. Ling, T. Mandrup-Poulsen, E. von Mutius, M.J. Makela, T. Paunio, G. Pershagen, H. Renz, G. Rook, M. Saarela, O. Vaarala, M. Veldhoen, W.M. de Vos. Helsinki alert of biodiversity and health. Ann Med 47(3):218-25, (2015). PMID:25904094.
T. Wang, X. Zhan, C.H. Bu, S. Lyon, D. Pratt, S. Hildebrand, J.H. Choi, Z. Zhang, M. Zeng, K.W. Wang, E. Turer, Z. Chen, D. Zhang, T. Yue, Y. Wang, H. Shi, J. Wang, L. Sun, J. SoRelle, W. McAlpine, N. Hutchins, X. Zhan, M. Fina, R. Gobert, J. Quan, M. Kreutzer, S. Arnett, K. Hawkins, A. Leach, C. Tate, C. Daniel, C. Reyna, L. Prince, S. Davis, J. Purrington, R. Bearden, J. Weatherly, D. White, J. Russell, Q. Sun, M. Tang, X. Li, L. Scott, E.M. Moresco, G.M. McInerney, G.B. Karlsson Hedestam, Y. Xie, B. Beutler. Real-time resolution of point mutations that cause phenovariance in mice.Proc Natl Acad Sci U S A 112(5):E440-9, (2015). PMCID: PMC4321302.
S. Rommelaere, V. Millet, T.P. Vu Manh, T. Gensollen, P. Andreoletti, M. Cherkaoui-Malki, C. Bourges, B. Escaliere, X. Du, Y. Xia, J. Imbert, B. Beutler, Y. Kanai, B. Malissen, M. Malissen, A. Tailleux, B. Staels, F. Galland, P. Naquet. Sox17 regulates liver lipid metabolism and adaptation to fasting.PLoS One 9(8):e104925, (2014). PMCID: PMC4139292.
O.M. Siggs, N. Xiao, Y. Wang, H. Shi, W. Tomisato, X. Li, Y. Xia, B. Beutler. iRhom2 is required for the secretion of mouse TNF alpha. Blood May 1, (2012). PMID: 22550345.
E. Narni-Mancinelli, B.N. Jaeger, C. Bernat, A. Fenis, S. Kung, A. De Gassart, S. Mahmood, M. Gut, S.C. Heath, J. Estellé, E. Bertosio, F. Vely, L.N. Gastinel, B. Beutler, B. Malissen, M. Malissen, I.G. Gut, E. Vivier, S. Ugolini. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science 335:344-8, (2012). PMID: 22267813.
A.K. Kiemer, R.H. Senaratne, J. Hoppstadter, B. Diesel, L.W. Riley, K. Tabeta, S. Bauer, B. Beutler, B.L. Zuraw. Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria. Journal of Innate Immunity 1:29-45, (2009).
J. Chaix, M.S. Tessmer, K. Hoebe, N. Fuseri, B. Ryffel, M. Dalod, L. Alexopoulou, B. Beutler, L. Brossay, E. Vivier, T. Walzer. Cutting Edge: Priming of NK cells by IL-18. J Immunol. 181:1627-31, (2008).
B. Beutler. The Toll-like Receptors. In:Genetic Susceptibility to Infection. R.L Kaslow, J. McNicholl and A.V.S. Hill, eds. Oxford University Press, pg. 165, (2008).
Y. Kinjo, E. Tupin, D.Wu, M. Fujio, R. Garcia-Navarro, M.R-E-I. Benhnia, D.M. Zajonc, G. Ben-Menachem, G.D. Ainge, G.F. Painter, A. Khurana, K. Hoebe, S.M. Behar, B. Beutler, I.A. Wilson, M. Tsuji, T.J. Sellati, C-H. Wong, M. Kronenberg. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol., 7:978-986, (2006).
A. Casrouge, S-Y Zhang, C. Eidenschenk, E. Jouanguy, A. Puel, K. Yang, A. Alcais, C. Picard, N. Mahfoufi, N. Nicolas, L. Lorenzo, S. Plancoulaine, B. Senechal, F. Geissmann, K. Tabeta, K. Hoebe, X. Du, R. L. Miller, B. Heron, C. Mignot, T. B. de Villemeur, P. Lebon, O. Dulac, F. Rozenberg, B. Beutler, M. Tardieu, L. Abel, J-L. Casanova. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314:308-12, (2006).
B. Beutler, K. Hoebe, P. Georgel, X. Du. Forward genetic analysis of TLR pathways: A shared system for the detection of endotoxin and viral infection. Editor: T. Rich. In: Toll and Toll-like receptors: an immunologic perspective,Kluwer Academic/Plenum publishers, New York, NY, pages 168-177, (2005).
K. Hoebe, P. Georgel, S. Rutschmann, X. Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung, U. Zahringer, B. Beutler. CD36 is a sensor of diacylglycerides. Nature, 433:523-527, (2005).
B. Beutler. Innate Immunity. In: Williams Hematology, 7th Edition. Lichtman, M.A., Beutler, E., Kipps, T.J., Seligsohn, U., Kaushansky, K., and Prchal, J.T., eds. McGraw-Hill Medical Press, New York, NY, pp. 231-238, (2005).
B. Beutler. Microbial Pathogenesis and the discovery of Toll-like receptor function. In: Vaccine Adjuvants: Immunological and Clinical Principles. Hackett, C., and Harn, D.A., eds. Humana Press, Totowa, NJ, pg. 1-24, (2005).
B. Beutler. Toll-like Receptors: The Origins of Inflammation. In: The Cytokine Handbook 4th Edition. T.A. Thomson and M.T. Lotze eds., Academic Press, 809-822, (2003).
B. Beutler and S. Beutler. The pathogenesis of fever. In: Cecil Textbook of Medicine 22nd Edition. D. Ausiello eds., W.B. Saunders, Philadelphia, PA, (2003).
B. Beutler. TNF In: Encyclopedia of Hormones & Related Cell Regulators. H.L. Henry and A.W. Norman eds., Academic Press, San Diego, CA. 536-539, (2003).
B. Beutler. Innate Immune Sensing and the Toll-like Receptors. In: The Liver: Biology and Pathobiology. I.M. Arias, J.L. Boyer, F.V. Chisari, et al., eds., 4th Edition, Lippincott, Williams & Wilkins, Philadelphia, PA, 581-589, (2001).
B. Beutler and A. Poltorak. Toll we meet again. Nat. Immunol., 2:9-10, (2001).