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Xue Zhong, Jin Huk Choi, Sara Hildebrand, Sara Ludwig, Jianhui Wang, Evan Nair-Gill, Tzu-Chieh Liao, James J Moresco, Aijie Liu, Jiexia Quan, Qihua Sun, Duanwu Zhang, Xiaoming Zhan, Mihwa Choi, Xiaohong Li, Junmei Wang, Thomas Gallagher, Eva Marie Y Moresco, Bruce Beutler . RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice Proc Natl Acad Sci USA. 2022 May 3;119(18). PMID: 35482923
2021
Anne-Perrine Foray, Sophie Candon, Sara Hildebrand, Cindy Marquet, Fabrice Valette, Coralie Pecquet, Sebastien Lemoine, Francina Langa-Vives, Michael Dumas, Peipei Hu, Pere Santamaria, Sylvaine You, Stephen Lyon, Lindsay Scott, Chun Hui Bu, Tao Wang, Darui Xu, Eva Marie Y Moresco, Claudio Scazzocchio, Jean-François Bach, Bruce Beutler , Lucienne Chatenoud. De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes Proc Natl Acad Sci USA. 2021 Nov 23;118(47). PMID: 34782469
Lijing Su, Muhammad Athamna, Ying Wang, Junmei Wang, Marina Freudenberg, Tao Yue, Jianhui Wang, Eva Marie Y Moresco, Haoming He, Tsaffrir Zor, Bruce Beutler . Sulfatides are endogenous ligands for the TLR4-MD-2 complex Proc Natl Acad Sci USA. 2021 Jul 27;118(30). PMID: 34290146
Darui Xu, Stephen Lyon, Chun Hui Bu, Sara Hildebrand, Jin Huk Choi, Xue Zhong, Aijie Liu, Emre E Turer, Zhao Zhang, Jamie Russell, Sara Ludwig, Elena Mahrt, Evan Nair-Gill, Hexin Shi, Ying Wang, Duanwu Zhang, Tao Yue, Kuan-Wen Wang, Jeffrey A SoRelle, Lijing Su, Takuma Misawa, William McAlpine, Lei Sun, Jianhui Wang, Xiaoming Zhan, Mihwa Choi, Roxana Farokhnia, Andrew Sakla, Sara Schneider, Hannah Coco, Gabrielle Coolbaugh, Braden Hayse, Sara Mazal, Dawson Medler, Brandon Nguyen, Edward Rodriguez, Andrew Wadley, Miao Tang, Xiaohong Li, Priscilla Anderton, Katie Keller, Amanda Press, Lindsay Scott, Jiexia Quan, Sydney Cooper, Tiffany Collie, Baifang Qin, Jennifer Cardin, Rochelle Simpson, Meron Tadesse, Qihua Sun, Carol A Wise, Jonathan J Rios, Eva Marie Y Moresco, Bruce Beutler . Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning. Proc Natl Acad Sci USA. 2021 Jul 13;118(28). PMID: 34260399
Jonathan J Rios, Kristin Denton, Hao Yu, Kandamurugu Manickam, Shannon Garner, Jamie Russell, Sara Ludwig, Jill A Rosenfeld, Pengfei Liu, Jake Munch, Daniel J Sucato, Bruce Beutler , Carol A Wise. Saturation mutagenesis defines novel mouse models of severe spine deformity. Dis Model Mech. 2021 Jun 3. Online ahead of print. PMID: 34079997
Tao Yue, Xiaoming Zhan, Duanwu Zhang, Ruchi Jain, Kuan-Wen Wang, Jin Huk Choi, Takuma Misawa, Lijing Su, Jiexia Quan, Sara Hildebrand, Darui Xu, Xiaohong Li, Emre Turer, Lei Sun, Eva Marie Y Moresco, Bruce Beutler . SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science. 2021 May 14;372(6543). PMID: 33986151
Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q Feng, Qian Xu, Yongbo Lu, Robert E Hammer, Carol A Wise, Bruce Beutler . Germline saturation mutagenesis induces skeletal phenotypes in mice. J Bone Miner Res. 2021 Apr 27. Online ahead of print. PMID: 33905568
Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y Moresco, Bruce Beutler . N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization. Nat Commun. 2021 Mar 2;12(1):1379. PMID: 33654074
Evan Nair-Gill, Massimo Bonora, Xue Zhong, Aijie Liu, Amber Miranda, Nathan Stewart, Sara Ludwig, Jamie Russell, Thomas Gallagher, Paolo Pinton, Bruce Beutler . Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. EMBO J. 2021 Feb 25. Online ahead of print. PMID: 33630350
Fatima M Al-Fadhli, Manal Afqi, Mona Hamza Sairafi, Makki Almuntashri, Essa Alharby, Ghadeer Alharbi, Firoz Abdud Samad, Jamil Amjad Hashmi, Dimah Zaytuni, Ahmed A Bahashwan, Jin Huk Choi, Roy W A Peake, Bruce Beutler , Naif A M Almontashiri. Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes. Clin Genet. 2021 Jan 26. Online ahead of print. PMID: 33495992
2020
Lauretta El Hayek, Islam Oguz Tuncay, Nadine Nijem, Jamie Russell, Sara Ludwig, Kiran Kaur, Xiaohong Li, Priscilla Anderton, Miao Tang, Amanda Gerard, Anja Heinze, Pia Zacher, Hessa S Alsaif, Aboulfazl Rad, Kazem Hassanpour, Mohammad Reza Abbaszadegan, Camerun Washington, Barbara R DuPont, Raymond J Louie, CAUSES Study; Madeline Couse, Maha Faden, R Curtis Rogers, Rami Abou Jamra, Ellen R Elias, Reza Maroofian, Henry Houlden, Anna Lehman, Bruce Beutler , Maria H Chahrour. KDM5A mutations identified in autism spectrum disorder using forward genetics. Elife 2020 Dec 22;9:e56883. PMID: 33350388
Darui Xu, Stephen Lyon, Chun Hui Bu, Sara Hildebrand, Jin Huk Choi, Xue Zhong, Aijie Liu, Emre E. Turer, Zhao Zhang, Evan Nair-Gill, Hexin Shi, Ying Wang, Duanwu Zhang, Tao Yue, Jeff SoRelle, Takuma Misawa, Lei Sun, Jianhui Wang, Roxana Farokhnia, Andrew Sakla, Sara Schneider, Nathan Stewart, Hannah Coco, Gabrielle Coolbaugh, Braden Hayse, Sara Mazal, Dawson Medler, Brandon Nguyen, Edward Rodriguez, Andrew Wadley, Miao Tang, Xiaohong Li, Priscilla Anderton, Katie Keller, Lindsay Scott, Jiexia Quan, Sydney Cooper, Baifang Qin, Jennifer Cardin, Rochelle Simpson, Meron Tadesse, Qihua Sun, John Santoyo, Amy Bronikowski, Alexyss Johnson, Eva Marie Y. Moresco, Bruce Beutler. Candidate Explorer: a tool for discovery, evaluation, and display of mutations causing significant immune phenotypes. bioRxiv 2020 Nov 7.
Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler. Mechanism of negative regulation of NF-κB by N4BP1 bioRxiv 2020 Oct 22.
Jeffrey A SoRelle, Zhe Chen, Jianhui Wang, Tao Yue, Jin Huk Choi, Kuan-Wen Wang, Xue Zhong, Sara Hildebrand, Jamie Russell, Lindsay Scott, Darui Xu, Xiaowei Zhan, Chun Hui Bu, Tao Wang, Mihwa Choi, Miao Tang, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Eva Marie Y Moresco, Bruce Beutler. Dominant atopy risk mutations identified by mouse forward genetic analysis Allergy 2020 Aug 18. Online ahead of print. PMID: 32810290
Xiaoming Zhan, Xue Zhong, Jin Huk Choi, Lijing Su, Jianhui Wang, Evan Nair-Gill, Priscilla Anderton, Xiaohong Li, Miao Tang, Jamie Russell, Sara Ludwig, Thomas Gallagher, Bruce Beutler. Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood Blood Adv. 2020 Aug 11;4(15):3594-3605. PMID: 32761233
Michele Carbone, Sarah T Arron, Bruce Beutler , Angela Bononi, Webster Cavenee, James E Cleaver, Carlo M Croce, Alan D'Andrea, William D Foulkes, Giovanni Gaudino, Joanna L Groden, Elizabeth P Henske, Ian D Hickson, Paul M Hwang, Richard D Kolodner, Tak W Mak, David Malkin, Raymond J Monnat Jr, Flavia Novelli, Harvey I Pass, John H Petrini, Laura S Schmidt, Haining Yang. Tumour Predisposition and Cancer Syndromes as Models to Study Gene-Environment Interactions. Nat Rev Cancer. 2020 May 29. Online ahead of print. PMID: 32472073
Bo Chen, Bogale Aredo, Yi Ding, Xin Zhong, Yuanfei Zhu, Cynthia X Zhao, Ashwani Kumar, Chao Xing, Laurent Gautron, Stephen Lyon, Jamie Russell, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Ludwig, Eva Marie Y Moresco, Bruce Beutler , Rafael L Ufret-Vincenty. Forward Genetic Analysis Using OCT Screening Identifies Sfxn3 Mutations Leading to Progressive Outer Retinal Degeneration in Mice. Proc Natl Sci USA. 2020 Jun 6;117(23):12931-12942. Epub May 26. PMID: 32457148
Zhao Zhang, Thomas Gallagher, Philipp E Scherer, Bruce Beutler. Tissue-specific Disruption of Kbtbd2 Uncovers Adipocyte-Intrinsic and -Extrinsic Features of the teeny Lipodystrophy Syndrome Proc Natl Sc USA 2020 May 26;117(21):11829-11835. Epub 2020 May 7. PMID: 32381739
Xue Zhong, Lijing Su, Yi Yang, Evan Nair-Gill, Miao Tang, Priscilla Anderton, Xiaohong Li, Jianhui Wang, Xiaoming Zhan, Diana R Tomchick, Chad A Brautigam, Eva Marie Y Moresco, Jin Huk Choi, Bruce Beutler. Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function Proc Natl Sc USA 2020 April 14;117(15):8563-8572. Epub 2020 Mar 27. PMID: 32220963
Choi JH, Zhong X, Zhang Z, Su L, McAlpine W, Misawa T, Liao TC1, Zhan X, Russell J, Ludwig S, Li X, Tang M, Anderton P, Moresco EMY, Beutler B . Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development. J Exp Med. 2020 Apr 6;217(4). PMID: 31985756
Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan X, Li X, Tang M, Gallagher T, Yu G, Beutler B. Essential requirement for nicastrin in marginal zone and B-1 B cell development. Proc Natl Acad Sci USA. 2020 Mar 3;117(9):4894-4901. Epub 2020 Feb 18. PMID: 32071239
Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B. Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation. Sci Immunol. 2020 Jan 24;5(43). PMID: 31980486
2019
Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B . Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40. Nat Immunol. 2019 Oct; 20(10):1322-1334. PMID: 31427773
Deng M, Guo H, Tam JW, Johnson BM, Brickey WJ, New JS, Lenox A, Shi H, Golenbock DT, Koller BH, McKinnon KP, Beutler B , Ting JP. Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR. J Exp Med. 2019 Sep 26 [Epub ahead of print]. PMID: 31558613
McAlpine W, Russell J, Murray AR, Beutler B , Turer E. Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology. J Invest Dermatol. 2019 Sept;139(9):1848-1853. PMID: 31445571
Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B , Schnabl B. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad USA. 2019 July 23;116(30):15184-15193. PMID: 31289229
Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B . Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice. Proc Natl Acad USA. 2019 June 4;116(23):11380-11389. PMID: 31097594
Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B . LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science. 2019 May 10;364(6440). PMID: 31073040
Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EMY, Boger DL, Beutler B , Zhang H. Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim. J Med Chem. 2019 Mar 28;62(6):2938-2949. PMID: 30829478
2018
Turer EE, San Miguel M, Wang KW, McAlpine W, Ou F, Li X, Tang M, Zang Z, Wang J, Hayse B, Evers B, Zhan X, Russell J, Beutler B . A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis. Dis Model Mech. 2018 Dec 18; 11(12). PMID: 30563851
McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, Choi M, Li X, Tang M, Moresco EMY, Beutler B , Turer E. Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. Proc Natl Acad Science USA. 2018 Dec 4; 115(49):E11523-E11531. Epub 2018 Nov 15. PMID: 30442666
Morin MD, Wang Y, Jones BT, Mifune Y, Su L, Shi H2, Moresco EMY, Zhang H, Beutler B , Boger DL. Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists. J Am Chem Soc. 2018 Oct 31; 140 (43):14440-14454. Epub 2018 Oct 16. PMID: 30272974
McAlpine W, Wang KW, Choi JH, San Miguel M, McAlpine SG, Russell J, Ludwig S, Li X, Tang M, Zhan X, Choi M, Wang T, Bu CH, Murray AR, Moresco EMY, Turer EE, Beutler B. The class I myosin MYO1D binds to lipid and protects against colitis. Dis Model Mech. 2018 Sep 27; 11(9). PMID: 30279225
Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, Siegwart DJ, Moresco EMY, Zhang H, Boger DL, Beutler B . Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice. Proc Natl Acad Sci USA. 2018 Sep 11;115(37):E8698-E8706. Epub 2018 Aug 27. PMID: 30150374
Pedersen GK, Li X, Khoenkhoen S, Ádori M, Beutler B , Karlsson Hedestam. B-1a Cell Development in Splenectomized Neonatal Mice. Front Immunol. 2018 Jul 30;9:1738. PMID: 30105023
Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B , Liu Q. Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat Commun . 2018 May 23;9(1):2041. PMID: 29795268
Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B , Herz J, Scherer PE. Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. J Clin Invest. 2018 Mar 1;128(3):1178-1189. PMID: 29457786
Wang T, Bu CH, Hildebrand S, Jia G, Siggs OM, Lyon S, Pratt D, Scott L, Russell J, Ludwig S, Murray AR, Moresco EMY, Beutler B . Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database. Nat Commun. 2018 Jan 30;9(1):441. PMID: 29382827
Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, Choi JH, Dosenovic P, Karlsson MCI, Beutler B , Karlsson Hedestam GB. Altered Marginal Zone B Cell Selection in the Absence of IκBNS. J Immunol. 2018 Jan 15;200(2):775-787. Epub 2017 Dec 8. PMID: 29222168
2017
Pollard KM, Escalante GM, Huang H, Haraldsson KM, Hultman P, Christy JM, Pawar RD, Mayeux JM, Gonzalez-Quintial R, Baccala R, Beutler B , Theofilopoulos AN, Kono DH. Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN. J Immunol . 2017 Dec 1;199(11):3739-3747. Epub 2017 Oct 20. PMID: 29055005
Mager LF, Koelzer VH, Stuber R, Thoo L, Keller I, Koeck I, Langenegger M, Simillion C, Pfister SP, Faderl M, Genitsch V, Tcymbarevich I, Juillerat P, Li X, Xia Y, Karamitopoulou E, Lyck R, Zlobec I, Hapfelmeier S, Bruggmann R, McCoy KD, Macpherson AJ, Müller C, Beutler B , Krebs P. The ESRP1-GPR137 axis contributes to intestinal pathogenesis. Elife. 2017 Oct 4;6. PMID: 28975893
Sun L, Jiang Z, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang J, Wang KW, Kilaru GK, Mohawk JA, Quan J, Scott L, Hildebrand S, Li X, Tang M, Zhan X, Murray AR, La Vine D, Moresco EMY, Takahashi JS, Beutler B. HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. J Exp Med. 2017 Nov 6;214(11):3263-3277. Epub 2017 Oct 2. PMID: 28970238
Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B. An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue. Sci Rep. 2017 Sep 15;7(1):11717. PMID: 28916811
D. Zhang, W. Tomisato, L. Su, L. Sun, J.H. Choi, Z. Zhang, K.W. Wang, X. Zhan, M. Choi, X. Li, M. Tang, J.M. Castro-Perez, S. Hildebrand, A. R. Murray, E.M.Y. Moresco, B. Beutler. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Proc Natl Acad Sci U S A
L. Israel, Y. Wang, K. Bulek, E. Della Mina, Z. Zhang, V. Pedergnana, M. Chrabieh, N.A. Lemmens, V. Sancho-Shimizu, M. Descatoire, T. Lasseau, E. Israelsson, L. Lorenzo, L. Yun, A. Belkadi, A. Moran, L.E. Weisman, F. Vandenesch, F. Batteux, S. Weller, M. Levin, J. Herberg, A. Abhyankar, C. Prando, Y. Itan, W.J. van Wamel, C. Picard, L. Abel, D. Chaussabel, X. Li, B. Beutler , P.D. Arkwright, J.L. Casanova, A. Puel. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell 2017 168(5):789-800. PMID: 28235196.
J.H. Choi, K.W. Wang, D. Zhang, X. Zhan, T. Wang, C.H. Bu, C.L. Behrendt, M. Zeng, Y. Wang, T. Misawa, X. Li, M. Tang, X. Zhan, L. Scott, S. Hildebrand, A.R. Murray, E.M. Moresco, L.V. Hooper, B. Beutler . IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice. Proc Natl Acad Sci U S A
E. Turer, W. McAlpine, K.W. Wang, T. Lu, X. Li, M. Tang, X. Zhan, T. Wang, X. Zhan, C.H. Bu, A.R. Murray, Beutler B . Creatine maintains intestinal homeostasis and protects against colitis. Proc Natl Acad Sci U S A
X. Li, T. Maretzky, J.M. Perez-Aguilar, S. Monette, G. Weskamp, S. Le Gall, B. Beutler , H. Weinstein, C.P. Blobel. Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2/ADAM17-dependent proteolysis. J Cell Sci. 2017 Jan 19. PMID:28104813.
C. Viant, S. Guia, R.J. Hennessy, J. Rautela, K. Pham, C. Bernat, W. Goh, Y. Jiao, R. Delconte, M. Roger, V. Simon, F. Souza-Fonseca-Guimaraes, S. Grabow, G.T. Belz, B.T. Kile, A. Strasser, D. Gray, P.D. Hodgkin, B. Beutler , E. Vivier, S. Ugolini, N.D. Huntington. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. J Exp Med
2016
B. Beutler . Innate immunity and the new forward genetics. Best Pract Res Clin Haematol . H. Shi, A. Murray, B. Beutler . Reconstruction of the Mouse Inflammasome System in HEK293T Cells. Bio Protoc . 2016 Nov 5;6(21). PMID:28516117.
Z. Zhang, E. Turer, X. Li, X. Zhan, M. Choi, M. Tang, A. Press, S.R. Smith, A. Divoux, E.M. Moresco, B. Beutler . Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proc Natl Acad Sci U S A
C.J. Groß, R. Mishra, K.S. Schneider, G. Médard, J. Wettmarshausen, D.C. Dittlein, H. Shi, O. Gorka, P.A. Koenig, S. Fromm, G. Magnani, T. Ćiković, L. Hartjes, J. Smollich, A.A. Robertson, M.A. Cooper, M. Schmidt-Supprian, M. Schuster, K. Schroder, P. Broz, C. Traidl-Hoffmann, B. Beutler , B. Kuster, J. Ruland, S. Schneider, F. Perocchi, O. Groß. K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria . Immunity
B. Beutler . Finding New Components of the Mammalian Immune System. Rambam Maimonides Med 2016 Jul 28;7(3). PMID: 27487306.J.Q. Wang, B. Beutler , C.C. Goodnow, K. Horikawa. Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo. Blood 2016 Jun 25. [Epub ahead of print]. PMID: 27458005.
O.M. Siggs, A. Stockenhuber, M. Deobagkar-Lele, K.R. Bull, T.L. Crockford, B.L. Kingston, G. Crawford, C. Anzilotti, V. Steeples, S. Ghaffari, G. Czibik, M. Bellahcene, H. Watkins, H. Ashrafian, B. Davies, A. Woods, D. Carling, A. Yavari, B . Beutler , R.J. Cornall. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A
M.D. Morin, Y. Wang, B.T. Jones, L. Su, M.M. Surakattula, M. Berger, H. Huang, E.K. Beutler, H. Zhang, B. Beutler , D.L. Boger. Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists. J Med Chem
G.K. Pedersen, M. Ádori, J.M. Stark, S. Khoenkhoen, C. Arnold, B . Beutler , G.B. Karlsson Hedestam. Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens. Front Immunol
Y. Wang, L. Su, M.D. Morin, B.T. Jones, L.R. Whitby, M.M. Surakattula, H. Huang, H. Shi, J.H. Choi, K.W. Wang, E.M. Moresco, M. Berger, X. Zhan, H. Zhang, D.L. Boger, B. Beutler . TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A
H. Shi, Y. Wang, X. Li, X. Zhan, M. Tang, M. Fina, L. Su, D. Pratt, C.H. Bu, S. Hildebrand, S. Lyon, L. Scott, J. Quan, Q. Sun, J. Russell, S. Arnett, P. Jurek, D. Chen, V.V. Kravchenko, J.C. Mathison, E.M. Moresco, N.L. Monson, R.J. Ulevitch, B. Beutler . NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol 17(3):250-8, (2016). PMID:26642356.return to top
2015
B. Beutler , C.A. Thaiss. Q&A: Chance encounters. Nature 526(7574):S59-60, (2015). PMID:26488245.M.M. Simon, E.M. Moresco, K.R. Bull, S. Kumar, A.M. Mallon, B. Beutler , P.K. Potter. Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing. Mamm Genome 26(9-10):486-500, (2015). PMCID: PMC4602060.
O.M. Siggs, D.L. Popkin, P. Krebs, X. Li, M. Tang, X. Zhan, M. Zeng, P. Lin, Y. Xia, M.B. Oldstone, R.J. Cornall, B. Beutler . Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proc Natl Acad Sci U S A 112(42):E5706-14, (2015). PMCID: PMC4620900.
L.A. Miosge, M.A. Field, Y. Sontani, V. Cho, S. Johnson, A. Palkova, B. Balakishnan, R. Liang, Y. Zhang, S. Lyon, B. Beutler , B. Whittle, E.M. Bertram, A. Enders, C.C. Goodnow, T.D. Andrews. Comparison of predicted and actual consequences of missense mutations. Proc Natl Acad Sci U S A 112(37):E5189-98, (2015). PMCID: PMC4577149.
L.F. Mager, C. Riether, C.M. Schürch, Y. Banz, M.H. Wasmer, R. Stuber, A.P. Theocharides, X. Li, Y. Xia, H. Saito, S. Nakae, G.M. Baerlocher, M.G. Manz, K.D. McCoy, A.J. Macpherson, A.F. Ochsenbein, B. Beutler , P. Krebs. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest 125(7):2579-91, (2015). PMCID:PMC4563674.
L. von Hertzen, B. Beutler , J. Bienenstock, M. Blaser, P.D. Cani, J. Eriksson, M. Farkkila, T. Haahtela, I. Hanski, M.C. Jenmalm, J. Kere, M. Knip, K. Kontula, M. Koskenvuo, C. Ling, T. Mandrup-Poulsen, E. von Mutius, M.J. Makela, T. Paunio, G. Pershagen, H. Renz, G. Rook, M. Saarela, O. Vaarala, M. Veldhoen, W.M. de Vos. Helsinki alert of biodiversity and health . Ann Med 47(3):218-25, (2015). PMID:25904094.
T. Wang, X. Zhan, C.H. Bu, S. Lyon, D. Pratt, S. Hildebrand, J.H. Choi, Z. Zhang, M. Zeng, K.W. Wang, E. Turer, Z. Chen, D. Zhang, T. Yue, Y. Wang, H. Shi, J. Wang, L. Sun, J. SoRelle, W. McAlpine, N. Hutchins, X. Zhan, M. Fina, R. Gobert, J. Quan, M. Kreutzer, S. Arnett, K. Hawkins, A. Leach, C. Tate, C. Daniel, C. Reyna, L. Prince, S. Davis, J. Purrington, R. Bearden, J. Weatherly, D. White, J. Russell, Q. Sun, M. Tang, X. Li, L. Scott, E.M. Moresco, G.M. McInerney, G.B. Karlsson Hedestam, Y. Xie, B. Beutler . Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci U S A
P. Dosenovic, M. Adori, W.C. Adams, G.K. Pedersen, M. Soldemo, B. Beutler, G.B. Karlsson Hedestam. Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Immunol Cell Biol
M.J. Jiménez-Dalmaroni, C.M. Radcliffe, D.J. Harvey, M.R. Wormald, P. Verdino, G.D. Ainge, D.S. Larsen, G.F. Painter, R. Ulevitch, B. Beutler , P.M. Rudd, R.A. Dwek, I.A. Wilson. Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunol 21(2):175-193, (2015). PMCID:PMC4392886.return to top
2014
G.K. Pedersen, M. Adori, S. Khoenkhoen, P. Dosenovic, B. Beutler , G.B. Karlsson Hedestam. B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS. Proc Natl Acad Sci U S A
S. Rommelaere, V. Millet, T.P. Vu Manh, T. Gensollen, P. Andreoletti, M. Cherkaoui-Malki, C. Bourges, B. Escaliere, X. Du, Y. Xia, J. Imbert, B. Beutler , Y. Kanai, B. Malissen, M. Malissen, A. Tailleux, B. Staels, F. Galland, P. Naquet. Sox17 regulates liver lipid metabolism and adaptation to fasting. PLoS One 9(8):e104925, (2014). PMCID: PMC4139292.
E. Colak, A. Leslie, K. Zausmer, E. Khatamzas, A.V. Kubarenko, T. Pichulik, S.N. Klimosch, A. Mayer, O. Siggs, A. Hector, R. Fischer, B. Klesser, A. Rautanen, M. Frank, A.V. Hill, B. Manoury, B. Beutler , D. Hartl, A. Simmons, A.N. Weber. RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling Events. J Immun 192(12):5963-73, (2014). PMCID: PMC4066583.
Z. Chen, W. Holland, J.M. Shelton, A. Ali, X. Zhan, S. Won, W. Tomisato, C. Liu, X. Li, E.M. Moresco, B. Beutler . Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling. Proc Natl Acad Sci U S A 111(20):7367-72, (2014). PMCID:PMC4034201.
J.Q. Wang, Y.S. Jeelall, B. Beutler , K. Horikawa, C.C. Goodnow. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med 211(3):413-26, (2014). PMCID:PMC3949567.
S.R. Garrison, A.D. Weyer, M.E. Barabas, B.A. Beutler , K. Horikawa, C.C. Goodnow. A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons. Pain 155(5):896-905, (2014). PMCID:PMC3989381. return to top
2013
K. Tabeta, K. Hoebe, E.M. Janssen, Y. Xia, B. Beutler . Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice." Nat Immunol
E.M. Moresco, X. Li, B. Beutler . Going forward with genetics: recent technological advances and forward genetics in mice . Am J Pathol 182:1462-73, (2013). PMID:23608223.
Y.T. Koh, J.C. Scatizzi, J.D. Gahan, B.R. Lawson, R. Baccala, K.M. Pollard, B.A. Beutler , A.N. Theofilopoulos, D.H. Kono. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells . J Immunol 190(10):4982-90, (2013). PMID: 23589617.
C.E. Teh, K. Horikawa, C.N. Arnold, B. Beutler , E.M. Kucharska, C.G. Vinuesa, E.M. Bertram, C.C. Goodnow, A. Enders. Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation . Genes Immun 14(4):223-33, (2013). PMID:23552399.
K.R. Bull, A.J. Rimmer, O.M. Siggs, L.A. Miosge, C.M. Roots, A. Enders, E.M. Bertram, T.L. Crockford, B. Whittle, P.K. Potter, M.M. Simon, A.M. Mallon, S.D. Brown, B. Beutler , C.C. Goodnow, G. Lunter, R.J. Cornall. Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations . PLoS Genet 9:e1003219, (2013). PMCID: PMC3561070.
R. Baccala, R. Gonzalez-Quintial, A.L. Blasius, I. Rimann, K. Ozato, D.H. Kono, B. Beutler , A.N. Theofilopoulous. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus . Proc Natl Acad Sci USA 110:2940-5, (2013). PMCID: PMC3581947.return to top
2012
O.M. Siggs, J. Cruite, X. Du, S. Rutschmann, E. Masliah, B. Beutler , M. Oldstone. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proc Natl Acad Sci USA 109(34):13733-8, (2012). PMID:22869751.
O.M. Siggs, N. Xiao, Y. Wang, H. Shi, W. Tomisato, X. Li, Y. Xia, B. Beutler . iRhom2 is required for the secretion of mouse TNF alpha. Blood May 1, (2012). PMID: 22550345.
S. Rutschmann, K. Crozat, X. Li, X. Du, J.C. Hanselman, A.A. Shigeoka, K. Brandl, D.L. Popkin, D.B. McKay, Y. Xia, E.M. Moresco, B. Beutler . Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice . G3 (Bethesda) 2(4):499-504, (2012). PMCID: PMC3337478.
E. Narni-Mancinelli, B.N. Jaeger, C. Bernat, A. Fenis, S. Kung, A. De Gassart, S. Mahmood, M. Gut, S.C. Heath, J. Estellé, E. Bertosio, F. Vely, L.N. Gastinel, B. Beutler , B. Malissen, M. Malissen, I.G. Gut, E. Vivier, S. Ugolini. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses . Science 335:344-8, (2012). PMID: 22267813.
K. Brandl, W. Tomisato, B. Beutler . Inflammatory bowel disease and ADAM17 deletion . N Engl J Med 366:190, (2012). PMID: 22236242.
O.M. Siggs, X. Li, Y. Xia, B. Beutler . ZBTB1 is a determinant of lymphoid development . J Exp Med 209:19-27, (2012). PMID: 22201126.
S. Won, C. Eidenschenk, C.N. Arnold, O.M. Siggs, L. Sun, K. Brandl, T.M. Mullen, G.R. Nemerow, E.M. Moresco, B. Beutler . Increased susceptibility to DNA virus infection in mice with a GCN2 mutation .J Virol 86:1802-8, (2012). PMID: 22114338.return to top
2011
P. Krebs, W. Fan, Y.H. Chen, K. Tobita, M.R. Downes, M.R. Wood, L. Sun, X. Li, Y. Xia, N. Ding, J.M. Spaeth, E.M. Moresco, T.G. Boyer, C.W. Lo, J. Yen, R.M. Evans, B. Beutler . Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet . Proc Natl Acad Sci USA 108:19678-82, (2011). PMID: 22106289.
E.M. Moresco and B. Beutler . Resisting viral infection: the gene by gene approach . Curr Opin Virol 1(6):513-8, (2011). PMID: 22440911.
A.L. Blasius, A.E. Dubin, M.J. Petrus, B.K. Lim, A. Narezkina, J.R. Criado, D.N. Wills, Y. Xia, E.M. Moresco, C. Ehlers, K.U. Knowlton, A. Patapoutian, B. Beutler . Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype . Proc Natl Acad Sci USA 108:19413-8, (2011). PMID: 22087007.
A.N. Theofilpoulos, D.H. Kono, B. Beutler , R. Baccala. Intracellular nucleic acid sensors and autoimmunity . J Interferon Cytokine Res 31:867-86, (2011). PMID: 22029446.
L. Krieg, O. Milstein, P. Krebs, Y. Xia, B. Beutler , X. Du. Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice . Blood
E.M. Moresco, D. LaVine, B. Beutler . Prion-like behavior of MAVS in RIG-I signaling . Cell Res 21:1643-5, (2011). PMID: 21931357.
D.E. Zak, F. Schmitz, E.S. Gold, A.H. Diercks, J.J. Peschon, J.S. Valvo, A. Niemistö, I. Podolsky, S.G. Fallen, R. Suen, T. Stolyar, C.D. Johnson, K.A. Kennedy, M.K. Hamilton, O.M. Siggs, B. Beutler , A. Aderem. Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses . Proc Natl Acad Sci USA 108(28):11536-41, (2011). PMCID: PMC3136315
I. Eleftherianos, S. Won, S. Chtarbanova, B. Squiban, K. Ocorr, R. Bodmer, B. Beutler , J.A. Hoffmann, J.L. Imler. ATP-sensitive potassium channel (KATP)-dependent regulation of cardiotropic viral infections . Proc Natl Acad Sci USA 108(29):12024-9, (2011). PMCID: PMC3141999
E.M. Moresco, D. LaVine, Beutler B . Toll-like receptors . Curr. Biol. 21(13):R488-93, (2011).
C.H. Xia, E. Lu, H. Liu, X. Du, B. Beutler, X. Gong. The Role of VLDLR in Intraretinal Angiogenesis in Mice . IOVS 52(9):6572-9, (2011).
P. Krebs, K. Crozat, D. Popkin, M.B. Oldstone, B. Beutler . Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice . Blood, 117:6582-8, (2011).
O.M. Siggs, B. Schnabl, B. Webb, B. Beutler . X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C . Proc Natl Acad Sci USA 108(19):7890-5, (2011). PMCID: PMC3093471
E.M. Moresco and B. Beutler . Special Delivery: Granulin Brings CpG DNA to Toll-like Receptor 9 . Immunity 34:453-5, (2011).
O.M. Siggs, C.N. Arnold, C. Huber, E. Pirie, Y. Xia, P. Lin, D. Nemazee, B. Beutler . The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow . Nat Immunol . 12(5):434-40, (2011). PMCID: PMC3079768
D.L. Popkin, J.R. Teijaro, B.M. Sullivan, S. Urata, S. Rutschmann, J.C. de la Torre, S. Kunz, B. Beutler, M. Oldstone. Hypomorphic mutation in the site-1 protease mbtps1 endows resistance to persistent viral infection in a cell-specific manner . Cell Host Microbe 9(3):212-22, (2011). PMCID: PMC3058147
C. Iavarone, K. Ramsauer, A.V. Kubarenko, J.C. Debasitis, I. Leykin, A.N. Weber, O.M. Siggs, B. Beutler , P. Zhang, G. Otten, U. D'Oro, N.M. Valiante, M.L. Mbow, A. Visintin. A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding . J Immunol. 186(7):4213-22, (2011).
S. Beutler and B. Beutler . Ernest Beutler: his life and contribution to medical science . Br J Haematol., 152(5):543-50, (2011).
K. Crozat, C. Eidenschenk, B.N. Jaeger, P. Krebs, S. Guia, B. Beutler , E. Vivier, S. Ugolini. Impact of β2 integrin deficiency on mouse Natural Killer cell development and function . Blood, 117(10):2874-82, (2011).
C.N. Arnold, Y. Xia, P. Lin, C. Ross, M. Schwander, N.G. Smart, U. Müller, B. Beutler . Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation Analysis . Genetics ,187(3):633-41, (2011). PMCID: PMC3063661
B. Beutler and C.C. Goodnow. How host defense is encoded in the mammalian genome .Mamm Genome 22(1-2):1-5, (2011).return to top
2010
M. Guma, J. Kashiwakura, B. Crain, Y. Kawakami, B. Beutler , G.S. Firestein, T. Kawakami, M. Karin, Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis . Proc Natl Acad Sci USA 107(51):22122-7, (2010). PMCID: PMC3009768
P.C. Ronald and B. Beutler . Plant and animal sensors of conserved microbial signatures . Science 330(6007):1061-4, Review, (2010).
K. Brandl, L. Sun, C. Neppl, O.M. Siggs, S.M. Le Gall, W. Tomisato, X. Li, X. Du, D.N. Maennel, C.P. Blobel, B. Beutler . MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands . Proc Natl Acad Sci USA 107(46):19967-19972, (2010). PMCID: PMC2993336
A.L. Blasius, C.N. Arnold, P. Georgel, S. Rutschmann, Y. Xia, P. Lin, C. Ross, X. Li, N.G. Smart, B. Beutler . Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells . Proc Natl Acad Sci USA 107(46):19973-19978, (2010). PMCID: PMC2993408
Y. Xia, S. Won, X. Du, P. Lin, C. Ross, D. La Vine, S. Wiltshire, G. Leiva, S.M. Vidal, B. Whittle, C.C. Goodnow, J. Koziol, E.M. Moresco, B. Beutler . Bulk Segregation Mapping of Mutations in Closely Related Strains of Mice . Genetics ,186(4):1139-46, (2010). PMCID: PMC2998299
M.B. Melo, P. Kasperkovitz, A. Cerny, S. Könen-Waisman, E.A. Kurt-Jones, E. Lien, B. Beutler , J.C. Howard, D.T. Golenbock, R.T. Gazzinelli. UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii . PLoS Pathog. 6(8). pii: e1001071, (2010). PMCID: PMC2928809
G. Wingender, P. Krebs, B. Beutler, M. Kronenberg. Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency . J Immunol. 185(5):2721-9, (2010).
Z. Orinska, N. Föger, M. Huber, J. Marschall, F. Mirghomizadeh, X. Du, M. Scheller, P. Rosenstiel, T. Goldmann, A. Bollinger, B.A. Beutler , S. Bulfone-Paus. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development . Blood Journal , 116(15):2665-75, (2010).
C. Eidenschenk, K. Crozat, P. Krebs, R. Arens, D. Popkin, C.N. Arnold, A.L. Blasius, C.A. Benedict, E.M. Moresco, Y. Xia, B. Beutler . Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells . Proc Natl Acad Sci USA 107(21):9759-64, (2010). PMCID: PMC2906899
A.L. Blasius and B. Beutler . Intracellular toll-like receptors . Immunity 32(3):305-15, (2010).
M. Berger, P. Krebs, K. Crozat, X. Li, B.A. Croker, O.M. Siggs, D. Popkin, X. Du, B.R. Lawson, A.N. Theofilopoulos, Y. Xia, K. Khovananth, E.M.Y. Moresco, T. Satoh, O. Takeuchi, S. Akira, B. Beutler . An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence . Nat Immunol. 11(4):335-43, (2010). PMCID: PMC2861894
M.J. Barnes, H. Aksoylar, P. Krebs, T. Bourdeau, C.N. Arnold, Y. Xia, K. Khovananth, I. Engel, S. Sovath, K. Lampe, E. Laws, A. Saunders, G.W. Butcher, M. Kronenberg, K. Steinbrecher, D. Hildeman, H.L. Grimes, B. Beutler , K. Hoebe. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice . J Immunol. 184(7):3743-54, (2010).
A.N. Theofilopoulos, R. Gonzalez-Quintial, B.R. Lawson, Y.T. Koh, M.E. Stern, D.H. Kono, B. Beutler , R. Baccala. Sensors of the innate immune system: their link to rheumatic diseases . Nat Rev Rheumatol. 6(3):146-56, (2010).
E.M. Moresco and B. Beutler . LGP2: positive about viral sensing . Proc Natl Acad Sci USA , 107(4):1261-2, (2010). PMCID: PMC2824419
O.M. Siggs, M. Berger, P. Krebs, C.N. Arnold, C. Eidenschenk, C. Huber, E. Pirie, N.G. Smart, K. Khovananth, Y. Xia, G. McInerney, G.B. Karlsson Hedestam, D. Nemazee, B. Beutler . A mutation of Ikbkg causes immune deficiency without impairing degradation of I{kappa}B{alpha} . Proc Natl Acad Sci USA , 107(7):3046-51, (2010). PMCID: PMC2840324
R.A. Fock, S.L. Blatt, B. Beutler , J. Pereira, M. Tsujita, F.E. de Barros, P. Borelli. Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition . Nutrition . 26(10)1021-8, (2010).
O. Osborn, M. Sanchez-Alavez, S.E. Brownell, B. Ross, J. Klaus, J. Dubins, B. Beutler , B. Conti, T. Bartfai. Metabolic Characterization of a Mouse Deficient in All Known Leptin Receptor Isoforms . Cell Mol Neurobiol. 30(1):23-33, (2010). PMCID: PMC2813927
H. Liu, M. Wang, C.H. Xia, X. Du, J.G. Flannery, K.D. Ridge, B. Beutler, X. Gong. Severe retinal degeneration caused by a novel rhodopsin mutation . Investigative Ophthalmology & Visual Science 51(2):1059-65, (2010). PMCID: PMC2868463return to top
2009
N. Xiao, C. Eidenschenk, P. Krebs, K. Brandl, A.L. Blasius, Y. Xia, K. Khovananth, N.G. Smart, B. Beutler . The Tpl2 mutation sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. J Immunol. 183(12):7975-83,(2009).
M.J. Jimenez-Dalmaroni, N. Xiao, A.L. Corper, P. Verdino, G.D. Ainge, D.S. Larsen, G.F. Painter, P.M. Rudd, R.A. Dwek, K. Hoebe, B. Beutler, I.A. Wilson. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2, PLoS One 4(10):e7411, (2009). PMCID: PMC2760212
E. Slack, S. Hapfelmeier, B. Stecher, Y. Velykoredko, M. Stoel, M.A. Lawson, M.B. Geuking, B. Beutler , T.F. Tedder, W.D. Hardt, P. Bercik, E.F. Verdu, K.D. McCoy, A.J. Macpherson. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism . Science 325:617-620, (2009).
R. Baccala, R. Gonzalez-Quintial, B.R. Lawson, M.E. Stern, D.H. Kono, B. Beutler, A.N. Theofilopoulos. Sensors of the innate immune system: their mode of action . Nat Rev Rheumatol. 5:448-56, (2009).
K. Flür, R. Allam, D. Zecher, O. P. Kulkarni1, J. Lichtnekert, M. Schwarz1, B. Beutler , V. Vielhauer, H. J. Anders. Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5. Implications for viral infection-associated glomerulonephritis . The American Journal of Pathology 175(5):2014-22, (2009). PMCID: PMC2774065
J. Truksa, T. Gelbart, H. Peng, E. Beutler, B. Beutler, P. Lee. Suppression of the hepcidin-encoding gene Hamp1 permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6 . British Journal of Haematology 147(4):571-81, (2009).
D.H. Kono, M.K. Haraldsson, B.R. Lawson, K.M. Pollard, Y.T. Koh, X. Du, C.N. Arnold, R. Baccala, G.J. Silverman, B.A. Beutler, A.N. Theofilopoulos. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 106(29):12061-6, (2009). PMCID: PMC2715524
R. Fukui, S. Saitoh, F. Matsumoto, H. Kozuka-Hata, M. Oyama, K. Tabeta, B. Beutler, K. Miyake. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med. 206(6):1339-50, (2009). PMCID: PMC2715051
P. Borelli, F.E. Barros, K. Nakajima, S.L. Blatt, B. Beutler , J. Pereira, M. Tsujita, G.M. Favero, R.A. Fock. Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates . Braz J Med Biol Res. 42(6):523-30, (2009).
S.C. Pflugfelder, M.E. Stern; Symposium Participants. Immunoregulation on the ocular surface: 2nd Cullen Symposium . Ocul Surf 7(2):67-77, Review , (2009).
P. Krebs, M.J. Barnes, K. Lampe, K. Whitley, K.S. Bahjat, B. Beutler , E. Janssen, K. Hoebe. NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses . Blood 113(26):6593-602, (2009). PMCID: PMC2710917
B.A. Beutler. TLRs and innate immunity. Blood 113(7):1399–1407, (2009). PMCID: PMC2644070J. Lichtnekert, V. Vielhauer, D. Zecher, O.P. Kulkarni, S. Clauss, S. Segerer, V. Hornung, T.N. Mayadas, B. Beutler , S. Akira, H.J. Anders. Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif . Am J Physiol Renal Physiol . 296(4):F867-74, (2009).
M.J. Barnes, P. Krebs, N. Harris, C. Eidenschenk, R. Gonzalez-Quintial, C.N. Arnold, K. Crozat, S. Sovath, E.M. Moresco, A.N. Theofilopoulos, B. Beutler, K. Hoebe. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery . PLoS Biology 7(3):e51, (2009). PMCID: PMC2650725
A.L. Blasius, K. Brandl, K. Crozat, Y. Xia, K. Khovananth, P. Krebs, N.G. Smart, A. Zampolli, Z.M. Ruggeri, B.A. Beutler. Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function . Proc Natl Acad Sci USA 106(8):2706-11, (2009). PMCID: PMC2650330
K. Brandl, S. Rutschmann, X. Li, X. Du, N. Xiao, B. Schnabl, D.A. Brenner, B. Beutler . Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response . Proc Natl Acad Sci USA 106(9):3300-5, (2009). PMCID: PMC2651297
A.K. Kiemer, R.H. Senaratne, J. Hoppstadter, B. Diesel, L.W. Riley, K. Tabeta, S. Bauer, B. Beutler, B.L. Zuraw. Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria. Journal of Innate Immunity 1:29-45, (2009).
B. Beutler . Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases . Immunological Reviews 227:248-263, (2009). PMCID: PMC2713013return to top
2008
A.A. Brzezinska, J.L. Johnson, D.B. Munafo, K. Crozat, B. Beutler , W.B. Kiosses, B.A. Ellis, S.D. Catz. The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules . Traffic 9(12): 2151-2164, (2008).
B.A. Croker, B.R. Lawson, M. Berger, C. Eidenschenk, A.L. Blasius, E.M. Moresco, S. Sovath, L. Cengia, L.D. Shultz, A.N. Theofilopoulos, S. Pettersson, B.A. Beutler . Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger . Proc Natl Acad Sci USA 105:15028-33, (2008). PMCID: PMC2567487
X. Du, M. Schwander, E.M. Moresco, P. Viviani, C. Haller, M.S. Hildebrand, K. Pak, L. Tarantino, A. Roberts, H. Richardson, G. Koob, H. Najmabadi, A.F. Ryan, R.J. Smith, U. Muller, B. Beutler . A catechol-O-methyltransferase that is essential for auditory function in mice and humans . Proc Natl Acad Sci USA 105:14609-14614, (2008). PMCID: PMC2567147
J. Chaix, M.S. Tessmer, K. Hoebe, N. Fuseri, B. Ryffel, M. Dalod, L. Alexopoulou, B. Beutler , L. Brossay, E. Vivier, T. Walzer. Cutting Edge: Priming of NK cells by IL-18 . J Immunol . 181:1627-31, (2008).
B. Beutler , I.W. Milsark, A.C. Cerami. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin . J Immunol . 181:7-9, (2008).X. Du, E. She, T. Gelbart, J. Truksa, P. Lee, Y. Xia, K. Khovananth, S. Mudd, N. Mann, E.M. Moresco, E. Beutler, B. Beutler . The serine protease TMPRSS6 is required to sense iron deficiency . Science 320:1088-92, (2008). PMCID: PMC2430097
P. Georgel, X. Du, K. Hoebe, B. Beutler . ENU Mutagenesis in Mice . Methods Mol Biol. 415:1-16, (2008).
M.A. Freudenberg, S. Tchaptchet, S. Keck, G. Fejer, M. Huber, N. Schutze, B. Beutler, C. Galanos. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity . Immunobiology 213:193-203, (2008).
K. Hoebe and B. Beutler . Forward genetic analysis of TLR-signaling pathways: An evaluation . Adv Drug Deliv Rev. 60:824-9, (2008).
B. Beutler and E.M. Moresco. The forward genetic dissection of afferent innate immunity. Curr Top Microbiol Immunol. 321:3-26, (2008).B. Beutler . Immunology, phenotype first. Preface . Curr Top Microbiol Immunol .321:v-viii, (2008).C.H. Xia, H. Liu, D. Cheung, M. Wang, C. Cheng, X. Du, B. Chang, B. Beutler, X. Gong. A model for familial exudative vitreoretinopathy caused by LPR5 mutations . Hum Mol Genet. 17:1605-12, (2008).
B. Beutler and E.M. Moresco. Akirins vs. Infection . Nat Immunol. 9:7-9, (2008).B. Beutler . The Toll-like Receptors. In:Genetic Susceptibility to Infection . R.L Kaslow, J. McNicholl and A.V.S. Hill, eds. Oxford University Press, pg. 165, (2008).return to top
2007
J. Koehn, D. Huesken, M. Jaritz, A. Rot, M. Zurini, A. Dwertmann, B. Beutler, U. Korthäuer. Assessing the function of human UNC-93B in TLR signaling and MHC II response . Human Immunol. , 68:871-78, (2007).
B. Croker, K. Crozat, M. Berger, Y. Xia, S. Sovath, L. Schaffer, I. Eleftherianos, J.L. Imler, B. Beutler . ATP-Sensitive Potassium channels mediate survival during infection in mammals and insects . Nat. Genet., 39: 1453-60, (2007).
B. Beutler . Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease . Immunol Rev., 220:113-28, (2007).B. Beutler , C. Eidenschenk, K. Crozat, J. Imler, J. Hoffman, O. Takeuchi, S. Akira. Genetic Analysis of Resistance to Viral Infection . Nat. Rev. Immunol., 7:753-766, (2007).J. H. Han, S. Akira, K. Calame, B. Beutler , E. Selsing, T. Imanishi-Kari. Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors . Immunity, 1:64-75, (2007).
P. Georgel, Z. Jiang, E. Kunz, J. Janssen, K. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone, B. Beutler . Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway . Virology, 362:304-313, (2007).
K. R. Taylor, K. Yamasaki, K. A. Radek, A. Di Nardo, H. Goodarzi, D. Golenbock, B. Beutler, R. L. Gallo. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on TLR4, CD44 and MD-2 . J. Biol.Chem., 282:18265-75, (2007).
D. Togbe, L. Schofield, G.E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler , V.F.J. Quesniaux, B. Ryffel. Murine cerebral malaria development is independent of Toll-like receptor signaling . Am. J. Pathol., 170:1640-1648, (2007).
K. Crozat, K. Hoebe, S. Ugolini, N. A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier, B. Beutler . Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis . J. Exp. Med., 204:853-863, (2007).
M.M. Brinkmann, E. Spooner, K. Hoebe, B. Beutler , H.L. Ploegh, Y-M. Kim. The interaction between the ER membrane protein UNC93B and TLRs 3, 7, and 9 is crucial for TLR signaling . J. Cell Biol., 177:265-275, (2007).
R. Baccala, K. Hoebe, D.H. Kono, B. Beutler, A. N. Theofilopoulos. Toll-like receptor-dependent and independent pathways of Type I interferon induction in systemic autoimmunity . Nat. Med., 13:543-551, (2007).
D.B. Munafó, J.L. Johnson, B.A. Ellis, S. Rutschmann, B. Beutler, S.D. Catz. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes . Biochem. J., 402:229-39, (2007).
S.O. Kim, S.D. Ha, S. Lee, S. Stanton, B. Beutler, J. Han. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells . Biotechniques, 42: 493-501, (2007).
B. Beutler , X. Du, Y. Xia. Precis on forward genetics in mice . Nat. Immunol., 8:659-664 (2007).M. Otsuka, Q. Jing, P. Georgel, L. New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S.C. Das, A.K. Pattnaik, J. Carlos de la Torre, B. Beutler, J. Han. Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression . Immunity, 27:123-124, (2007).return to top
2006
M. Huber, C. Kalis, S. Keck, Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, B. Beutler , C. Galanos, M.A. Freudenberg. R-form LPS, the master key to the activation of TLR4/MD2 positive cells . Eur. J. Immunol., 36:701-711, (2006).
B. Beutler , Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du, K. Hoebe. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large . Annu. Rev. Immunol., 24:353-389, (2006).E. M. Janssen, K. Tabeta, M. Barnes, S. McBride, S. Schoenberger, A.N. Theofilopoulos, B. Beutler, K. Hoebe. Efficient T cell activation via a toll-interleukin 1 receptor-independent pathway . Immunity , 24:787-799, (2006).
K. Tabeta, K. Hoebe, E.M Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, J. Goode, L. Shamel, A. Herskovits, D. Portnoy, M. Cooke, L.M. Tarantino, T. Wiltshire, B.E. Steinberg, S. Grinstein, B. Beutler . The Unc93b1 mutation 3d disrupts exogenous antigen presentation signaling via Toll-like receptors 3, 7, and 9 . Nat. Immunol. 7:156-164, (2006).
S. Rutschmann, K. Hoebe, J. Zalevsky, X. Du, N. Mann, B.I. Dahiyat, P. Steed, B. Beutler . PanR1 , a dominant negative missense allele of Tumor Necrosis Factor a , does not impair lymphoid developmentJ. Immunol., 176:7525-7532, (2006).
K. Crozat, P. Georgel, S. Rutschmann, N. Mann, X. Du, K. Hoebe, B. Beutler . Analysis of the MCMV resistome by ENU mutagenesis . Mamm. Genome, 17:398-406, (2006).
Z. Jiang, P. Georgel, C. Li, J. Choe, K. Crozat, S. Rutschmann, X. Du, T. Bigby, S. Mudd, S. Sovath, I.A. Wilson, A. Olson, B. Beutler . Details of Toll-like receptor: adapter interaction revealed by germline mutagenesis . Proc. Natl. Acad. Sci. U.S.A. , 103:10961-10966, (2006).
D. Nemazee, A.L. Gavin, K. Hoebe, B. Beutler . Commentary: The TLR independence of antibody responses . Nature, 441: E4, (2006).
K. Hoebe, Z. Jiang, K. Tabeta, X. Du, P. Georgel, K. Crozat, B. Beutler . Genetic analysis of innate immunity . Adv. in Immunol., 91:175-226, (2006).
K. Hoebe, Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du, B. Beutler. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy . Curr. Pharm. Des, 12: 4123-4134, (2006).
H. Fischer, M. Yamamoto, S. Akira, B. Beutler, C. Svanborg. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection . Eur. J. Immunol., 36:267-277, (2006).
C.H. Xia, H. Liu, D. Cheung, C. Cheng, E. Wang, X. Du, B. Beutler . Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis . Development , 133: 2033-2040, (2006).
K. Hoebe and B. Beutler . TRAF3: a new component of the TLR-signaling apparatus . Trends Mol. Med., 12:187-189, (2006).
L. Gitlin, W. Barchet, S. Gilfillan, M. Cella, B. Beutler , R.A. Flavell, M.S. Diamond, M. Colonna. Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus . Proc. Natl. Acad. Sci. U.S.A., 103:8459-8464, (2006).
Y. Kinjo, E. Tupin, D.Wu, M. Fujio, R. Garcia-Navarro, M.R-E-I. Benhnia, D.M. Zajonc, G. Ben-Menachem, G.D. Ainge, G.F. Painter, A. Khurana, K. Hoebe, S.M. Behar, B. Beutler , I.A. Wilson, M. Tsuji, T.J. Sellati, C-H. Wong, M. Kronenberg. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria . Nat. Immunol., 7:978-986, (2006).
A. Casrouge, S-Y Zhang, C. Eidenschenk, E. Jouanguy, A. Puel, K. Yang, A. Alcais, C. Picard, N. Mahfoufi, N. Nicolas, L. Lorenzo, S. Plancoulaine, B. Senechal, F. Geissmann, K. Tabeta, K. Hoebe, X. Du, R. L. Miller, B. Heron, C. Mignot, T. B. de Villemeur, P. Lebon, O. Dulac, F. Rozenberg, B. Beutler , M. Tardieu, L. Abel, J-L. Casanova. Herpes simplex virus encephalitis in human UNC-93B deficiency . Science, 314:308-12, (2006).
D. Togbe, G. Aurore, N. Noulin, V.F. Quesnizux, S. Schnyder-Candrian, B. Schnyder , V. Vasseur, S. Akira, K. Hoebe, B. Beutler , B. Ryffel, I. Couillin. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways . LabInvest., 86:1126-1135, (2006).
T.P. Meehan, K. Tabeta, X. Du, L.S. Woodward, K. Firozi, B. Beutler, M.J. Justice. Point mutations in the melanocortin-4 receptor cause variable obesity in mice . Mamm. Genome , 17:1162-1171, (2006).
A.L. Gavin, B. Duong, T. Ota, K. Hoebe, B. Beutler , D. Nemazee. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling . Science , 314:1936-1938, (2006).
B. Beutler. Fighting malaria: mosquitoes know how . Immunity, 25:530-531, (2006).C.H. Xia, H. Liu, M. Wang, D. Heung, A. Park, Y. Yang, X. Du, B. Chang, B. Beutler , X. Gong. Characterization of mouse mutants with abnormal RPE cells . Adv. Exp. Med. Biol., 572:95-100, (2006).return to top
2005
A.N. Theofilopoulos, R. Baccala, B. Beutler , D.H. Kono. Type I interferons (a/ß) in immunity and autoimmunity . Annu. Rev. of Immunol. , 23:307-335, (2005).
B. Beutler , K. Hoebe, P. Georgel, X. Du. Forward genetic analysis of TLR pathways: A shared system for the detection of endotoxin and viral infection. Editor: T. Rich. In: Toll and Toll-like receptors: an immunologic perspective, Kluwer Academic/Plenum publishers, New York, NY, pages 168-177, (2005).K. Hoebe, P. Georgel, S. Rutschmann, X. Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung, U. Zahringer, B. Beutler . CD36 is a sensor of diacylglycerides . Nature, 433:523-527, (2005).
T.R. Hawn, A. Verbon, M. Janer, L.P. Zhao, B. Beutler , A. Aderem. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires disease . Proc. Natl. Acad. Sci. U.S.A., 102:2487-2489, (2005).
B. Beutler , K. Crozat, J.A. Koziol, P. Georgel. Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model . Curr. Opin. Immunol., 17:36-43, (2005).J. Mattner, K.L. DeBord, N. Ismail, R.D. Goff, C. Cantu III, D. Zhou, P. Sait-Mezard, V. Wang, Y. Gao, N. Yin, K. Hoebe, O. Schneewind, D. Walker, B. Beutler , L. Teyton, P.B. Savage, A. Bendelac. Both exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections . Nature 434:525-529, (2005).
P. Georgel, K. Crozat, X. Lauth, S. Sovath, K. Hoebe, X. Du, S. Rutschmann, Z. Jiang, T. Bigby, V. Nizet, B. Beutler . A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial infections . Infect. Immun. , 73:4512-4521, (2005).
Z. Zhou, K. Hoebe, X. Du, Z. Jiang, L. Shamel, B. Beutler . Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 upregulation . Eur. J. Immunol., 35:1918-1927, (2005).
Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, B. Beutler . CD14 is required for MyD88-independent LPS signaling . Nat. Immunol., 6:565-570, (2005).
K. Hoebe and B. Beutler . Unraveling innate immunity using large scale ENU mutagenesis . Tissue Antigens, 65:395-401, (2005).
B. Beutler and J-L. Casanova. New frontiers in immunology: Workshop on the Road Ahead: Future directions in fundamental and clinical immunology . EMBO Rep., 6:620-623, (2005).B. Beutler, K. Hoebe, P. Georgel, K. Tabeta, X. Du. Genetic analysis of innate immunity: identification and function of the TIR adapter proteins . Adv. Exp. Med. Biol., 560:29-39 (2005).K.I. Kim, O. Malakhova, K. Hoebe, M. Yan, B. Beutler, D-E. Zhang. Enhanced anti-bacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulation type I IFN-signaling . J. Immunol., 175:847-854, (2005).
B. Beutler . The Toll-like receptors: Analysis by forward genetic methods . Immunogenetics, 57:385-392, (2005).C.W. Wieland, S. Florquin, N.A. Maris, K. Hoebe, B. Beutler , K. Takeda, S. Akira, T. van der Poll. The MyD88 dependent but not the MyD88 independent pathway of Toll-like receptor 4 signaling is important in clearing non-typeable Haemophilus influenzae from the mouse lung . J. Immunol., 175:6042-6049, (2005).
X. Du, K. Tabeta, K. Hoebe, N. Mann, K. Crozat, S. Mudd, B. Beutler . An essential role for Rxr a in Th2 development . Eur. J. Immunol, 35:3414-3423, (2005).
B. Beutler. Innate Immunity. In: Williams Hematology, 7th Edition. Lichtman, M.A., Beutler, E., Kipps, T.J., Seligsohn, U., Kaushansky, K., and Prchal, J.T., eds. McGraw-Hill Medical Press, New York, NY, pp. 231-238, (2005).B. Beutler , P. Georgel, B. Croker, K. Crozat. Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV) . Brief. Funct. Genomic Proteomic, 4:203-213, (2005).H.Q. Liu, X. Du, M. Wang, Q.L. Huang, L.L. Ding, H.W. McDonald, J.R. Yates, B. Beutler , J. Horwitz, X.H. Gong. Crystallin gamma B-14F mutant protein binds to alpha-crystallin and affects lens transparency . J.Biol.Chem. 280:25071-25078, (2005).
B. Beutler. Microbial Pathogenesis and the discovery of Toll-like receptor function. In: Vaccine Adjuvants: Immunological and Clinical Principles . Hackett, C., and Harn, D.A., eds. Humana Press, Totowa, NJ, pg. 1-24, (2005).return to top
2004
X. Du, K. Tabeta, K. Hoebe, H. Liu, N. Mann, S. Mudd, K. Crozat, S. Sovath, X. Gong, B. Beutler. Velvet , a dominant Egfr mutation that causes wavy hair and defective eyelid development in miceGenetics , 166:331-340, (2004).
K. Tabeta, P. Georgel, E.M. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, L. Alexopoulou, R. Flavell, B. Beutler . TLR9 and TLR3 as essential components of innate immune defense against mouse cytomegalovirus infection . Proc. Natl. Acad. Sci. U.S.A., 101:3516-3521, (2004).
N. Anfossi, S.H. Robbins, S. Ugolini, P. Georgel, K. Hoebe, C. Bouneaud, C. Ronet, A. Kaser, C.B. DiCioccio, E. Tomasello, B. Beutler, S.L. Reiner, L. Alexopoulou, O. Lantz , D.H. Raulet, L. Brossay, E. Vivier. Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules . J. Immunol., 173:3773-3782, (2004).
K. Crozat and B. Beutler . TLR7: A new sensor of viral infection . Proc. Natl. Acad. Sci. U.S.A., 101:6835-6836, (2004).
B. Beutler. Preview: SHIP, TGF-ß, and Endotoxin Tolerance . Immunity, 21:134-135, (2004).K. Hoebe, E.M. Janssen, B. Beutler . The Interface between Innate and Adaptive Immunity . Nat. Immunol., 5:971-974, (2004).
B. Beutler . The Toll-like receptors and their place in immunology: Where does the immune response to infection begin? Nat. Rev. Immunol., 4:498 (2004).B. Beutler . Inferences, questions and possibilities in Toll-like receptor signaling . Nature, 430:257-263, (2004).K. Hoebe and B. Beutler . LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins . J. Endotoxin Res., 10:130-136, (2004).
I. Smythe, X. Du, M.S. Taylor, M. Justice, B. Beutler, I.J. Jackson. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis . Proc. Natl. Acad. Sci. U.S.A., 101:13560-13565, (2004).
H. Weighardt, G. Jusek, J. Mages, R. Lang, K. Hoebe, B. Beutler, B. Holzmann. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells . Eur. J. Immunol., 34:558-564, (2004).
B. Beutler. Innate Immunity: an overview . Mol. Immunol., 40:845-859, (2004).B. Beutler , K. Hoebe, L. Shamel. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses . C. R. Biol., 327:571-80, (2004).B. Beutler and J. Hoffmann. Innate immunity: Editorial overview. Curr. Opin. Immunol., 16:1-3, (2004).B. Beutler , K. Hoebe, P. Georgel, K. Tabeta, X. Du. Genetic analysis of innate immunity: TLR adapter proteins in innate and adaptive immune responses . Microbes Infection, 6:1374-1381, (2004).E.T. Rietschel, M. Rietschel, B. Beutler . How the mighty have fallen: fatal infectious diseases of divine composers . Editors: B.A. Cunha and R.C. Moellering. In: Infectious Diseases Clinics of North America , W.B. Saunders Company, Philadelphia, PA, 18:311-339, (2004).return to top
2003
B. Beutler. Toll-like Receptors: The Origins of Inflammation. In: The Cytokine Handbook 4th Edition. T.A. Thomson and M.T. Lotze eds., Academic Press, 809-822, (2003).B. Beutler and S. Beutler. The pathogenesis of fever. In: Cecil Textbook of Medicine 22nd Edition. D. Ausiello eds., W.B. Saunders, Philadelphia, PA, (2003).K. Hoebe, X. Du, J. Goode, N. Mann, B. Beutler . Lps2 : a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screeningJ.Endotox.Res., 9:250-255, (2003).
I. Smirnova, N. Mann, A. Dols, H.H. Derkx, M. Hibberd, M. Levin, B. Beutler . Assay of locus-specific genetic load implicates rare TLR4 mutations in meningococcal susceptibility . Proc. Natl. Acad. Sci. U.S.A., 100:6075-6080, (2003).
K. Hoebe, X. Du, P. Georgel, E.M. Janssen, K. Tabeta, S.O. Kim, J. Goode, P. Lin, N. Mann, S. Mudd, K. Crozat, S. Sovath, J. Han, B. Beutler. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling . Nature, 424:743-748, (2003).
K. Hoebe, E.M. Janssen, S.O. Kim, L. Alexopoulou, R.A. Flavell, J. Han, B. Beutler. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways . Nat. Immunol., 4:1223-1229, (2003).
T.R. Hawn, A. Verbon, K.D. Lettinga, L.P. Zhao, S.S. Li, R.J. Laws, S.J. Skerrett, B. Beutler, L. Schroeder, A. Nachman, A. Ozinsky, K.D. Smith, A. Aderem. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease . J. Exp. Med., 198:1563-1572, (2003).
B. Beutler. Innate immune responses to microbial poisons: Discovery and function of the Toll-like receptors . Annu. Rev. Pharmacol. Toxicol., 43:609-628, (2003).B. Beutler. Key inflammatory and stress pathways in critical illness the central role of the Toll-like receptors . Crit. Care, 7:39-46, (2003).B. Beutler and E.T. Rietschel. Innate immune sensing and its roots: the story of endotoxin . Nat. Rev. Immunol., 3:169-176, (2003).B.J. Stevenson, C. Iseli, B. Beutler, C.V. Jongeneel. Using transcriptome data to unravel the fine structure of genes involved in sepsis . J. Infect. Dis. , 187:S308-S314, (2003).
B. Beutler. TNF In: Encyclopedia of Hormones & Related Cell Regulators . H.L. Henry and A.W. Norman eds., Academic Press, San Diego, CA. 536-539, (2003).B. Beutler , X. Du, K. Hoebe. From phenomenon to phenotype, and from phenotype to gene: forward genetics and the problems of sepsis . J. Infect. Dis., 187:S321-326, (2003).B. Beutler , K. Hoebe, X. Du, R.J. Ulevitch. How we detect microbes and respond to them: the Toll-like receptors and their transducers . J. Leukoc. Biol. , 74:479-485, (2003).B. Beutler , K. Hoebe, X. Du, E.M. Janssen, P. Georgel, K. Tabeta. Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and virusesScan.J. Infect.Dis., 35:563-567, (2003).B. Beutler. Not "molecular patterns" but molecules . Immunity, 19:155-156 (2003).S.O. Kim, Q. Jing, K. Hoebe, B. Beutler , N.S. Duesbery, J. Han. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-a . J. Biol. Chem., 278:7413-7421, (2003).return to top
2002
B. Beutler. Toll-like receptors: how they work and what they do . Curr. Opin. Hematol. 9:2-10, (2002).B. Beutler. . Wien. Med. Wochenschr., 152:547-551, (2002). > B. Beutler. Endotoxin antagonism: conceptual basis and therapeutic potential . Expert Opin. Ther. Targets , 6:147-158, (2002).B. Beutler. TLR4 as the mammalian endotoxin sensor. In: Curr. Top. Microbiol. Immunol., B. Beutler and H. Wagner eds., Springer-Verlag, 109-120, (2002).B. Beutler and M. Rehli. Evolution of the TIR, Tolls and TLRs: functional inferences from computational Biology . Curr. Top. Microbiol. Immunol., B. Beutler and H. Wagner eds., Springer-Verlag, 1-21, (2002).B. Beutler. LPS in microbial pathogenesis: promise and fulfillment . J. Endotox. Res. , 8:329-335, (2002).B. Beutler and E. Beutler. Toll-like receptor 4 polymorphisms and atherogenesis . New Engl. J. Med. , 347:1978-1979, (2002).return to top
2001
I. Smirnova, M. Hamblin, C. McBride, B. Beutler , A. di Rienzo. Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans . Genetics , 158:1657-1664, (2001).
B. Beutler. Innate Immune Sensing and the Toll-like Receptors. In: The Liver: Biology and Pathobiology. I.M. Arias, J.L. Boyer, F.V. Chisari, et al., eds., 4th Edition, Lippincott, Williams & Wilkins, Philadelphia, PA, 581-589, (2001).B. Beutler and A. Poltorak. Toll we meet again . Nat. Immunol., 2:9-10, (2001).B. Beutler and A. Poltorak. The sole gateway to endotoxin response: how Lps was identified as Tlr4 , and its role in innate immunity . Drug Metab. Dispos., 29:474-78, (2001).B. Beutler and A. Poltorak. The Search for Lps : 1993-1998 . J. Endotox. Res. 6:269-293, (2001).B. Beutler. The Toll-like receptors as the primary sensors of the innate immune system. The Immunologist 8:123-130, (2001).D. Kimbrell and B. Beutler . Evolution and genetics of innate immunity . Nat. Rev. , 2:256-267, (2001).
B. Beutler , X. Du, A. Poltorak. Identification of Toll-like receptor 4 (TLR4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies . J. Endotox. Res., 7:277-280, (2001).B. Beutler and A. Poltorak. Sepsis and the evolution of the innate immune response . Crit. Care Med., 29:S2-7, (2001).B. Beutler. Autoimmunity and apoptosis: The Crohn's connection . Immunity, 15:5-14, (2001).H.R. Redl, A. Aderem, B. Beutler , T. Calandra, J.P. Mira, R. Ulevitch. Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components . Crit. Care Med., 29:S19-20, (2001).
R. Ulevitch and B. Beutler . Genetic analysis of host responses in sepsis . Curr. Infect. Dis. Rep., 3:419-426, (2001).
B. Beutler. Sepsis begins at the interface of pathogen and host . Biochem. Soc. Trans., 29:853-859, (2001).return to top
2000
A. Poltorak, P. Ricciardi-Castagnoli, S. Citterio, B. Beutler . Physical contact between LPS and TLR4 revealed by genetic complementation . Proc. Natl. Acad. Sci. U.S.A., 97:2163-2167, (2000).
I. Smirnova, A. Poltorak, E.K.L. Chen, C. McBride, B. Beutler . Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4) . Genome Biol. , 1:1-10, (2000).
J. Nattermann, X. Du, Y. Wei, D. Shevchenko, B. Beutler . Endotoxin-mimetic effect of antibodies against Toll-like receptor 4 . J. Endotox. Res., 6:257-264, (2000).
A. Poltorak, I. Smirnova, R. Clisch, B. Beutler . Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice . J.Endotox.Res., 6:51-56, (2000).
X. Du, A. Poltorak, Y. Wei, B. Beutler . Three novel mammalian toll-like receptors: gene structure, expression, and evolution . Eur. Cytokine Netw., 11:362-371, (2000).
M. Rehli, A. Poltorak, L. Schwarzfischer, S.W. Krause, R. Andreesen, B. Beutler . PU.1 and interferon consensus sequence-blinding protein regulate the myeloid expression of the human Toll-like receptor 4 gene . J. Biol. Chem., 275:9773-9781, (2000).
B. Beutler. Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity . Curr. Opin. Microbiol., 3:23-28, (2000).B. Beutler. TLR4: Central component of the sole mammalian LPS sensor . Curr. Opin. Immunol., 12:20-26, (2000).B. Beutler and A. Poltorak. Positional cloning of Lps and the general role of toll-like receptors in the innate immune response . Eur. Cytokine Netw., 11:143-152, (2000).return to top
1999
J.A. Koziol and B. Beutler . Estimation of physical distance in the genome through probabilistic analysis of marker density and yeast artificial chromosome (YAC) size . Biom. J. , 41: 251-257, (1999).
G.R. Brown, G. Lindberg, J. Meedings, M. Silva, B. Beutler, D.Thiele.Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease . Gastroenterology, 116:593-601, (1999).
X. Du, A. Poltorak, M. Silva, B. Beutler . Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor . Blood Cells Mol. Dis., 25:328-338, (1999).return to top
1998
A. Poltorak, I. Smirmova, X. He, M.-Y. Liu, C. Van Huffel, O. McNally, D. Birwell, E. Alejos, M. Silva, X. Du, P. Thompson, E.K.L. Chan, J. Ledesma, B. Roe, S. Clifton, S. Vogel, B. Beutler . Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region . Blood Cells Mol. Dis., 24:340-355, (1998).
A. Poltorak, X. He, I. Smirnova, M.-Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, B. Beutler . Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the TLR4 gene. Science , 282:2085-2088, (1998).
B. Beutler and F. Bazzoni. TNF, apoptosis and autoimmunity: a common thread? Blood Cells Mol. Dis., 24:216-230, (1998).G.R. Brown, M.D. Silva, P.A. Thompson, B. Beutler . Lymphoid hyperplasia, CD45RB high/low T cell imbalance, and suppression of type I diabetes mellitus result from TNF blockade in NOD 6 NOD-scid adoptive T cell transfer . Diabetologia, 41:1502-1510, (1998).return to top